Free PDF Pharmacokinetic-Pharmacodynamic Modeling and SimulationBy Peter L. Bonate
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Pharmacokinetic-Pharmacodynamic Modeling and SimulationBy Peter L. Bonate
Free PDF Pharmacokinetic-Pharmacodynamic Modeling and SimulationBy Peter L. Bonate
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This is a second edition to the original published by Springer in 2006. The comprehensive volume takes a textbook approach systematically developing the field by starting from linear models and then moving up to generalized linear and non-linear mixed effects models. Since the first edition was published the field has grown considerably in terms of maturity and technicality. The second edition of the book therefore considerably expands with the addition of three new chapters relating to Bayesian models, Generalized linear and nonlinear mixed effects models, and Principles of simulation. In addition, many of the other chapters have been expanded and updated.
- Sales Rank: #368961 in Books
- Published on: 2011-07-01
- Original language: English
- Number of items: 1
- Dimensions: 10.75" h x 8.00" w x 1.75" l, 3.45 pounds
- Binding: Hardcover
- 618 pages
From the Back Cover
Since its publication in 2006, Pharmacokinetic-Pharmacodynamic Modeling and Simulation has become the leading text on modeling of pharmacokinetic and pharmacodynamic data using nonlinear mixed effects models and has beenapplauded by students andteachersfor its readability and exposition of complex statisticaltopics. Using a building block approach, the text starts withlinear regression, nonlinear regression, and variance models at theindividual leveland then moves to population-level models withlinear and nonlinearmixed effects models. Particular emphasis is made highlighting relationships between the model types and how the models build upon one another.
With the second edition, new chapters on generalized nonlinear mixed effects models and Bayesian models are presented, along with an extensive chapter on simulation. In addition, many chapters have been updated to reflect recent developments. The theory behind the methods is illustrated using real data from the literature and from the author's experiences in drug development. Data are analyzed using a variety of software, including NONMEM, SAS, SAAM II,and WinBUGS. A key component of the book is to show how models are developed using an acceptance-rejection paradigm with the ultimate goal of using models to explain data, summarize complex experiments, andusesimulation to answer "what-if" questions. Scientists andstatisticians outside the pharmaceutical sciences will find the book invaluable as a reference forapplied modeling and simulation.
About the Author
Peter Bonate has 16 years industrial experience, 13 years as a clinical pharmacologist/pharmacokineticist andthree years in drug metabolism and bioanalysis. He is currently a Director in the Clinical Pharmacology, Modeling, and Simulation department at GlaxoSmithKline in the oncology and rare diseases therapeutic areas. He has worked at Genzyme, Hoechst Marion Roussel, Eli Lilly, and Quintiles. He received his PhD in 1996 from Indiana University in Medical Neurobiology with an emphasis on the pharmacokinetics of drugs of abuse. He received an MS in statistics from the University of Idaho and an MS in Pharmacology from Washington State University, both in 1990. In 2003 he was elected a Fellow of the American College of Clinical Pharmacology and in 2007 was elected a fellow of the American Association of Pharmaceutical Scientists (AAPS). He was founder of the Modeling and Simulation focus group, has served as chair of the population pharmacokinetics focus group, and was the Clinical Pharmacology and Translational Research Section Chair within AAPS. He has served or currently serves on the editorial boards for the Journal of Clinical Pharmacology, Pharmaceutical Research, Journal of Pharmacokinetics and Pharmacodynamics, and The AAPS Journal. He has more than 50 publications in the field of pharmacokinetics and clinical pharmacology, is co-editor of the 3-volume series Pharmacokinetics in Drug Development published by AAPS Press in 2004 and 2011, and is author of the book Pharmacokinetic-Pharmacodynamic Modeling and Simulation published by Springer in 2006. In 2010, he became an Adjunct Assistant Professor at the Indiana University School of Medicine and the University of North Carolina, Chapel Hill.
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